Tokuda Laboratory
Tokuda Laboratory, Department of Radiology

New R01 Project on MRI-Guided Robotic Arrhythmia-Ablation

Posted on 06/26/2023

Our collaborative team, consisting of scientists and clinicians from Georgia Institute of Technology (Georgia Tech), Johns Hopkins University (JHU) and Brigham and Women’s Hospital (BWH) have received a new R01 grant entitled “Improved arrhythmia ablation via MR-guided robotic catheterization and multimodal clinician feedback” from the National Institute of Biomedical Imaging and Bioengineering.

With this 4-year, $2.5M grant, we will develop a multimodal feedback-based navigation system and MR- compatible robotic platform that enables precise, continuous, and permanent lesion creation during MR-guided radiofrequency ablation (RFA) for atrial fibrillation (AF) treatment.

The project will be led by Drs. Yue Chen, Ph.D. (Georgia Tech), Aravindan Kolandaivelu, M.D. (JHU), Ehud Schmidt, Ph.D. (JHU), and Junichi Tokuda, Ph.D. (BWH). The BWH team will provide a software system that integrates image processing, visualization, and robot control using the software infrastructure developed through a separate R01 project.

  1. Schmidt EJ, Olson G, Tokuda J, Alipour A, Watkins RD, Meyer EM, Elahi H, Stevenson WG, Schweitzer J, Dumoulin CL, Johnson T, Kolandaivelu A, Loew W, Halperin HR. Intracardiac MR imaging (ICMRI) guiding-sheath with amplified expandable-tip imaging and MR-tracking for navigation and arrythmia ablation monitoring: Swine testing at 1.5 and 3T. Magn Reson Med. 2022;87(6):2885–2900. doi:10.1002/mrm.29168 PMID: 35142398. PMCID: PMC8957513.
  2. Gunderman AL, Schmidt EJ, Morcos M, Tokuda J, Seethamraju RT, Halperin HR, Viswanathan AN, Chen Y. MR-Tracked Deflectable Stylet for Gynecologic Brachytherapy. IEEE ASME Trans Mechatron. 2022;27(1):407–417. doi:10.1109/tmech.2021.3064954 PMID: 35185321. PMCID: PMC8855967.
  3. Johnson M, Chen Y, Hovet S, Xu S, Wood B, Ren H, Tokuda J, Tse ZTH. Fabricating biomedical origami: a state-of-the-art review. Int J Comput Assist Radiol Surg. 2017;12(11):2023–2032. doi:10.1007/s11548-017-1545-1 PMID: 28260164. PMCID: PMC5922460.
  4. Wang W, Viswanathan AN, Damato AL, Chen Y, Tse Z, Pan L, Tokuda J, Seethamraju RT, Dumoulin CL, Schmidt EJ, Cormack RA. Evaluation of an active magnetic resonance tracking system for interstitial brachytherapy. Med Phys. 2015;42(12):7114–7121. doi:10.1118/1.4935535 PMID: 26632065. PMCID: PMC4662673.
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